Monograph

R03BA05 - Fluticasone

Not porphyrinogenic

Rationale

Probably no significant systemic load. Several references stating non-porphyrinogenicity of glucocorticoids.

Chemical description

Corticosteroid in inhalation aerosol (50 ug/dose) used in treatment of asthma. Plasma levels under detection limit. Used in porphyria ward (Sweden). glucocorticoids EPI-list: safe South African list: use Kalman, Bonkowski: safe The Merck Manual: safe Tschudy DP, Lamon JM: Porphyrin metabolism and the porphyrias, in Bondy PK, Rosenberg LE (eds.): Duncan's Diseases of Metabolism. Philadelphia, WB Saunders, 1980, p939: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe

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