Monograph

R05DA04 - Codeine

Propably not porphyrinogenic

Rationale

Opioid substrate for 2D6 and 3A4. Several references consider it safe for use.

Chemical description

Opioide with analgetic and antitussive properties. Demetylated by CYP 2D6 and 3A4. Inhibitor of 2D6. EPI-list: safe South African list: use French list: authorized Anderson KE: Effects of antihypertensive drugs on hepatic heme biosynthesis, and evaluation of ferrochelatase inhibitors to simplify testing of drugs for heme pathway induction. Biochem Biophys Acta 543:313, 1978: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe

IPNet drug reports

Uneventful use reported in 27 patients with acute porphyria.

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Tradenames

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