R06AD01 - Alimemazine |
Probably not porphyrinogenic |
PNP |
Rationale
Phenotiazines in general are considered safe in several references.
Chemical description
High dose (tabl 40-300 mg/d) phenotiazine neuroleptic with sedative and antiallergic properties, used e.g. as tranquilizer in alcoholism, as premedication, in itching and allergic conditions.
IPNet drug reports
Uneventful use reported in 6 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Effects of antihypertensive drugs on hepatic heme biosynthesis, and evaluation of ferrochelatase inhibitors to simplify testing of drugs for heme pathway induction.
Anderson KE. Biochim Biophys Acta. 1978 Oct; 543(3):313-27.
|
708789 |
| 2. | Management of acute attacks in the porphyrias.
Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.
|
9554242 |
| 3. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
| Porphyria Drug Lists | ||
| 4. | French List
Centre Français des Porphyries
|
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| 5. | South African List
Porphyria South Africa No longer maintained
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Tradenames
Theralene 
Variargil 
Alfresed · Alimemazine · Itzenal · Vallergan · Vallergan Forte 
Alfresed · Alimemazin · Nedeltran · Panectyl · Theralen · Theralene · Vallergan 
Alimemazin · Theralene 
Vallergan · Vallergan Forte 
Panectyl 
Alimemazin 
Alimemazina 
Alimemazine