Monograph
R06AD02 - Promethazine |
Propably not porphyrinogenic |
PNP |
Rationale
Substrate for 2B6 and 2D6. Phenotiazines in general are considered safe in several references.
Chemical description
High dose phenothiazine used (tabl 5-500 mg/d) as tranquillizer, antiallergic, and against motion sickness. Metabolized by CYPs 2B6 and 2D6, Inhibitor of 2 D6. Used in porphyria ward (Sweden). South African list: use French list: authorized Kalman, Bonkowski: safe Anderson KE: Effects of antihypertensive drugs on hepatic heme biosynthesis, and evaluation of ferrochelatase inhibitors to simplify testing of drugs for heme pathway induction. Biochem Biophys Acta 543:313, 1978: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe.
IPNet drug reports
Uneventful use reported in 6 patients with acute porphyria.
Similar drugs
Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Promethazine 
Farganesse 
Avomine · Phenergan · Phenergan Nightime · Promethazine · Promethazine teoclate · Sominex · Vertigon · Ziz · Ziz Forte 
Phenergan · Prometazin 
Phenergan · Promethazin 
Diphergan · Polfergan 
Phenergan · Prometazin
© NAPOS 2025