Monograph
R06AX02 - Cyproheptadine |
Possibly porphyrinogenic |
PSP |
Rationale
Insufficient data on metabolism. Compare loratadine (R06A X13): "Metabolised by CYP 3A4. Inducer of CYP 3A4. Two references consider it safe. Clinical experience (Swedish) seems to point to non-porphyrinogenicity. "
Chemical description
Dibencycloheptene methylpiperadine antihistamine, also effective against itching in neurodermatitis. Main metabolite is the glucuronide conjugate of the drug. Is also excreted in unchanged form in faeces. Structural analogue to loratidine. French list: authorized
Similar drugs
Tradenames
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Periactin 
Ciproheptadina 
Cyproheptadine · Periactin 
Cyproheptadine · Periactin · Peritol 
Peritol
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