Monograph
S01AA01 - Chloramphenicol |
Propably not porphyrinogenic |
PNP |
Rationale
Possibly insignificant systemic exposure
Chemical description
Broadspectrum antibiotic in eye drops 5mg/mL (one drop, i.e. About 100 µg, every third hour for two days). EPI-list: unsafe Kalman, Bonkovski: unsafe South African list: avoid French list: interdit
IPNet drug reports
Uneventful use reported in 3 patients with acute porphyria. One report of an acute porphyric attack in a susceptible male with AIP, but the attack was poorly documented. This report has therefore not been taken into account in the judgement of the porphyrinogenicity of chloramphenicol eye drops.
Similar drugs
Tradenames
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