Fluorescein is probably not metabolised by CYP. Side effects such as nausea and vomiting may be potentially porphyrinogenic through reduction in caloric intake.

Fluorescein sodium is a water-soluble synthetic salt with fluorescent properties.

Fluorescein is used both as a topical application (eye drops) and as an intravenous injection. Used topically, fluorescein stains damaged cornea and disrupted ocular fluids and is applied to the eye for the detection of corneal lesions and foreign bodies and to aid the fitting of hard contact lenses. It is also used in various other diagnostic ophthalmic procedures. The injection formulation is used in ophthalmic angiography and angioscopy. Common side effects such as nausea and vomiting may be potentially porphyrinogenic through reduction in caloric intake.

After injection fluorescein undergoes rapid metabolism to fluorescein monoglucuronide and is eliminated manly via renal excretion. Half-life is less than one hour. Probably no CYP metabolism, and fluorescein is not listed as an inducer or inhibitor of CYP (Rendic 2002, Zhou 2008)