Monograph
A10BA02 - Metformin |
Not porphyrinogenic |
NP |
Rationale
Metformin is not metabolized in the body. The physiological effects are not porphyrinogenic. Nausea and vomiting may be potentially porphyrinogenic through reduced caloric intake, but can be counteracted by suitable administration regimes. More than 30 observations of safe use by carriers of acute porphyria.
Chemical description
Biguanide antidiabetic.
Therapeutic characteristics
Metformin is indicated for the improvement of glycaemic control in adult patients with type 2 diabetes mellitus. It is administered orally. Common adverse reactions of metformin that can be confused with an acute porphyric attack are nausea, vomiting and abdominal pain.
Metabolism and pharmacokinetics
Eliminated unchanged via glomerular filtration.
Published experience
Kauppinen 1992: uneventfully used by one patient with acute porphyria.
IPNet drug reports
Uneventful use reported in 30 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Prognosis of acute porphyria: occurrence of acute attacks, precipitating factors, and associated diseases. Medicine (Baltimore). 1992 Jan; 71(1):1-13.
Kauppinen R, Mustajoki P. |
1549056 |
| 2. | Drug interactions with oral antidiabetic agents: pharmacokinetic mechanisms and clinical implications.
Tornio A, Niemi M, et al. Trends Pharmacol Sci. 2012 Jun; 33(6):312-22. |
22475684 |
| * | Summary of Product Characteristics | |
| 3. | The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). Glucophage.
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Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Glucient · Glycofren · Metformine 
Metformax · Metformin · Metformine 
Brotmin · Dianben · Metformina 
Glucophage · Keymet · Metfonorm · Metforal · Metforalmille · Metformina · Slowmet · Zuglimet 
Brotmin · Glucophage · Meguan · Metfogamma · Metformin · Metformina · Siofor · Xuvelex · Zenofor 
Axpinet · Bolamyn · Bolamyn SR · Diagemet · Glucient · Glucophage · Glucophage SR · Glucorex · Glyformin · Jesacrin · Meijumet · Metabet · Metabet SR · Metformin · Metsol · Metuxtan SR · Rudimet · Sukkarto · Sukkarto SR · Yaltormin · Yaltormin SR 
Forminet · Lyomet · Metformin · Mitforgen 
Glucophage · Metformin · Siofor 
Abmetfina · Avamina · Diabufor · Etform · Formetic · Glucophage · Iruka · Meladine · Metcrean · Metformax · Metformin · Normoton · Ranmet · Siofor · Symformin · Thinban · Valimar · Xuvelex · Zenofor 
Glucophage · Metformax · Metformin 
Forminet · Glucophage · Metformin 
Forminet · Glucophage · Metforem · Metformin · Oramet 
Brotmin · Glucophage · Metfogamma · Metforal · Metformin 
Glucophage · Gluformin · Meglucon · Metformin · Siofor · Tefor
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