Monograph

V01AA05 - Tree Pollen

Propably not porphyrinogenic

Rationale

Tree pollen extracts consists mainly of polypeptides and proteins that are not subject to liver metabolism or interaction with CYP enzymes.

Therapeutic characteristics

Allergen extracts containing tree pollen are used in allergy immunotherapy, to desensitize people that have an allergy to tree pollen. It is administered as a subcutaneous injection. It may be used continuously throughout the season or for up to 3to 5 years for long term efficacy (SPC).

Metabolism and pharmacokinetics

The allergen is presumably taken up by dendritic cells and presented to other cells of the immune system. It is not expected that the allergens is absorbed into the vascular system to any significant extent. No pharmacokinetic studies in animals or clinical studies have been conducted (EMEA, Pfaar 2014, SPC).

References

#	Citation details	PMID
*	Scientific articles
1.	Guideline on allergen-specific immunotherapy in IgE-mediated allergic diseases. Pfaar O, Bachert C, et al. Allergo J Int. 2014; 23(8): 282–319.	26120539
*	Government bodies
2.	EMEA. Committee for Medicinal Products for Human Use (CHMP) and Efficacy Working Party (EWP): Guideline on the clinical development of products for specific immunotherapy for the treatment of allergic diseases; EMEA/CHMP/EWP/18504/ 2006. 2008.
*	Summary of Product Characteristics
3.	Norwegian medicines agency. Summary of Product Characteristics (SPC). Alutard.

Citation details

PMID

Scientific articles

Guideline on allergen-specific immunotherapy in IgE-mediated allergic diseases.

Pfaar O, Bachert C, et al. Allergo J Int. 2014; 23(8): 282–319.

26120539

Government bodies

EMEA. Committee for Medicinal Products for Human Use (CHMP) and Efficacy Working Party (EWP): Guideline on the clinical development of products for specific immunotherapy for the treatment of allergic diseases; EMEA/CHMP/EWP/18504/

2006. 2008.

Summary of Product Characteristics

Norwegian medicines agency. Summary of Product Characteristics (SPC). Alutard.

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Tradenames and packages

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Netherlands

Birch Pollen Extract · Alutard SQ Berkpollen 100-100.000 SQ-E/ml, suspensie voor injectie · Alutard SQ Berkpollen 100.000 SQ-E/ml, suspensie voor injectie · Boom Pollen Extract · Pollinex boompollen Instel- en Onderhoudskuur, suspensie voor injectie in een voorgevulde spuit 300, 800 en 2000 SU/0,5 ml · Pollinex boompollen Instel- en Onderhoudskuur, suspensie voor injectie in injectieflacon 300, 800 en 2000 SU/0,5 ml · Pollinex boompollen Instelkuur, suspensie voor injectie in een voorgevulde spuit 300, 800 en 2000 SU/0,5 ml · Pollinex boompollen Instelkuur, suspensie voor injectie in injectieflacon 300, 800 en 2000 SU/0,5 ml · Pollinex boompollen Onderhoudskuur, suspensie voor injectie in een voorgevulde spuit 2000 SU/0,5 ml · Pollinex boompollen Onderhoudskuur, suspensie voor injectie in injectieflacon 2000 SU/0,5 ml · ITULAZAX · ITULAZAX 12 SQ-Bet lyofilisaat voor sublinguaal gebruik · ITULAZAX 12 SQ-Bet, lyofilisaat voor sublinguaal gebruik

Belgium

Itulazax lyoph. · Itulazax lyoph. or.

United Kingdom

Itulazax · Itulazax 12 SQ-Bet oral lyophilisates · Pollinex Trees · Pollinex Trees Extension Course 12,000units/3ml vaccine solution for injection vials · Pollinex Trees No 1 1,800units/3ml vaccine solution for injection vials · Pollinex Trees No 2 4,800units/3ml vaccine solution for injection vials · Pollinex Trees No 3 12,000units/3ml vaccine solution for injection vials · Pollinex Trees suspension for injection treatment and extension course vials · Pollinex Trees vaccine solution for injection pack · Pollinex Trees Extension Course · Pollinex Trees Extension Course suspension for injection 1.5ml vials · Pollinex Trees No 1 · Pollinex Trees No 1 suspension for injection 1ml vials · Pollinex Trees No 2 · Pollinex Trees No 2 suspension for injection 1ml vials · Pollinex Trees No 3 · Pollinex Trees No 3 suspension for injection 1ml vials

Denmark