Monograph

A10BB12 - Glimepiride

Propably not porphyrinogenic

Rationale

Glimepiride is metabolized by CYP2C9. There are no clinical studies indicating that glipizide is an inhibitor or inducer of CYP enzymes.

Chemical description

Sulfonylourea.

Therapeutic characteristics

Glimepirid is indicated for the treatment of diabetes type 2. Very rare side effects that can be potentially porphyrinogenic through reduction in carbohydrate intake and that also can be confused with an acute porphyria attack are nausea, vomiting, diarrhoea and abdominal pain. A rare side effect is hypoglycaemia, which also may be potentially porphyrinogenic.

Metabolism and pharmacokinetics

Glimepirid is metabolized mainly by CYP2C9 (Holstein 2012) and the elimination half-life is 5-8 hours. There are no clinical studies indicating that glipizide is an inhibitor or inducer of CYP enzymes.

IPNet drug reports

Uneventful use reported in 5 patients with acute porphyria.

Similar drugs

Explore alternative drugs in similar therapeutic classes A10B / A10BB or go back.

References

#	Citation details	PMID
*	Scientific articles
1.	CYP2C metabolism of oral antidiabetic drugs--impact on pharmacokinetics, drug interactions and pharmacogenetic aspects. Holstein A, Beil W, Kovacs P. Expert Opin Drug Metab Toxicol. 2012 Dec;8(12):1549-63.	23153186
*	Summary of Product Characteristics
2.	Norwegian medicines agency. Summary of Product Characteristics (SPC). (glimepirid).

Citation details

PMID

Scientific articles

CYP2C metabolism of oral antidiabetic drugs--impact on pharmacokinetics, drug interactions and pharmacogenetic aspects.

Holstein A, Beil W, Kovacs P. Expert Opin Drug Metab Toxicol. 2012 Dec;8(12):1549-63.

23153186

Summary of Product Characteristics

Norwegian medicines agency. Summary of Product Characteristics (SPC). (glimepirid).

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