Acute Porphyria Drugs

Acute Porphyria Drug Database

Monograph

A10BX02 - Repaglinide
Propably not porphyrinogenic
PNP
Rationale
Repaglinide does not induce or inhibit CYP3A4. Risk for gastrointestinal adverse events in the form of abdominal pain and diarrhoea motivates vigilance against insufficient intake of food, especially of carbohydrate.
Chemical description
Carbamoylmethyl benzoic acid derivative
Therapeutic characteristics
Repaglinide is indicated for the treatment of diabetes type 2 as monotherapy or in combination with metformin. Common side effects that can be potentially porphyrinogenic through reduction in carbohydrate intake and that also can be confused with an acute porphyria attack are abdominal pain and diarrhoea.
Hepatic exposure
Probably not significant
Metabolism and pharmacokinetics
Repaglinide is metabolized mainly by CYP2C8 and to a smaller degree by CYP3A4 (SPC). Repaglinide was co-administrated with theophylline, a CYP3A4 substrate, and did not induce or inhibit theophylline (Hatorp 2000).

References

# Citation details PMID
*Scientific articles
1. Drug interaction studies with repaglinide: repaglinide on digoxin or theophylline pharmacokinetics and cimetidine on repaglinide pharmacokinetics.
Hatorp V, Thomsen MS. J Clin Pharmacol. 2000 Feb;40(2):184-92.
 10664925
*Summary of Product Characteristics
2. Norwegian medicines agency. Summary of Product Characteristics (SPC). repaglinid.
Similar drugs
Explore alternative drugs in similar therapeutic classes A10B / A10BX or go back.
Tradenames and packages
From some sources, we get a list of packages (United Kingdom, Ireland, Estonia). Other sources contain more or less "clean" versions of the trade name (Denmark, Finland, Iceland, Lithuania, Norway). What you see here is the raw data we get from each country, so there will appear to be duplicates. The bold names are the searchable terms. The gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors. We strive to improve it continuously.
Netherlands
Enyglid · Enyglid 0,5 mg, tablets · Enyglid 1 mg, tablets · Enyglid 2 mg, tablets · NovoNorm · NovoNorm, 0,5 mg tabletten · NovoNorm, 1 mg tabletten · NovoNorm, 2 mg tabletten · Prandin · Prandin 0,5 mg, tabletten · Prandin 1 mg, tabletten · Prandin 2 mg, tabletten · Repaglinide · Repaglinide Accord 0,5 mg tabletten · Repaglinide Accord 1 mg tabletten · Repaglinide Accord 2 mg tabletten · Repaglinide Krka 0,5 mg tabletten · Repaglinide Krka 1 mg tabletten · Repaglinide Krka 2 mg tabletten · Repaglinide STADA 0,5 mg, tabletten · Repaglinide STADA 1 mg, tabletten · Repaglinide STADA 2 mg, tabletten · Repaglinide STADA 4 mg, tabletten · Repaglinide Teva 0,5 mg, tabletten · Repaglinide Teva 1 mg, tabletten · Repaglinide Teva 2 mg, tabletten
Belgium
Enyglid · Enyglid 0.5 mg comp. · Enyglid 1 mg comp. · Enyglid 2 mg comp. · NovoNorm · NovoNorm 0.5 mg comp. · NovoNorm 1 mg comp. · NovoNorm 2 mg comp. · Prandin · Prandin 0.5 mg comp. · Prandin 1 mg comp. · Prandin 2 mg comp. · Repaglinide · Repaglinide Accord 0.5 mg comp. · Repaglinide Accord 1 mg comp. · Repaglinide Accord 2 mg comp. · Repaglinide EG 0.5 mg comp. · Repaglinide EG 1 mg comp. · Repaglinide EG 2 mg comp. · Repaglinide Krka 0.5 mg comp. · Repaglinide Krka 1 mg comp. · Repaglinide Krka 2 mg comp. · Repaglinide Teva 0.5 mg comp. · Repaglinide Teva 1 mg comp. · Repaglinide Teva 2 mg comp.
United Kingdom
Enyglid · Enyglid 0.5mg tablets · Enyglid 1mg tablets · Enyglid 2mg tablets · NovoNorm · NovoNorm 1mg tablets · NovoNorm 2mg tablets · NovoNorm 500microgram tablets · Prandin · Prandin 0.5mg tablets · Prandin 1mg tablets · Prandin 2mg tablets · Repaglinide · Repaglinide 1mg tablets · Repaglinide 2mg tablets · Repaglinide 500microgram tablets
Denmark
Enyglid · NovoNorm · Prandin · Repaglinid · Repaglinid "Doc Generici" · Repaglinid "Teva" · Repaglinide · Repaglinide "Accord" · Repaglinide "Krka"
Norway
NovoNorm · Repaglinide Accord
Poland
Enyglid · NovoNorm · Prandin · Repaglinide Accord · Repaglinide Krka · Repaglinide Teva
Luxembourg
ENYGLID · ENYGLID-0,5 · ENYGLID-1 · ENYGLID-2 · NOVONORM · NOVONORM-0,5 · NOVONORM-1 · NOVONORM-2 · PRANDIN · PRANDIN-0,5 · PRANDIN-1 · PRANDIN-2 · Repaglinide · Repaglinide EG · REPAGLINIDE KRKA-0,5 · REPAGLINIDE KRKA-1 · REPAGLINIDE KRKA-2 · REPAGLINIDE MYLAN-2
Iceland
Enyglid · NovoNorm · Prandin · Repaglinide · Repaglinide Accord · Repaglinide Krka · Repaglinide Teva
Finland
Enyglid · Novonorm · Prandin · Repaglinid Stada · Repaglinide Accord · Repaglinide Krka · Repaglinide Teva
Latvia
Enyglid · NovoNorm · Prandin · Repaglinide · Repaglinide Accord · Repaglinide ELVIM · Repaglinide Krka · Repaglinide Teva
Serbia
GLUKOGLINID
 
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