Monograph

A10BX02 - Repaglinide

Propably not porphyrinogenic

Rationale

Repaglinide does not induce or inhibit CYP3A4. Risk for gastrointestinal adverse events in the form of abdominal pain and diarrhoea motivates vigilance against insufficient intake of food, especially of carbohydrate.

Chemical description

Carbamoylmethyl benzoic acid derivative

Therapeutic characteristics

Repaglinide is indicated for the treatment of diabetes type 2 as monotherapy or in combination with metformin. Common side effects that can be potentially porphyrinogenic through reduction in carbohydrate intake and that also can be confused with an acute porphyria attack are abdominal pain and diarrhoea.

Hepatic exposure

Probably not significant

Metabolism and pharmacokinetics

Repaglinide is metabolized mainly by CYP2C8 and to a smaller degree by CYP3A4 (SPC). Repaglinide was co-administrated with theophylline, a CYP3A4 substrate, and did not induce or inhibit theophylline (Hatorp 2000).

Similar drugs

Explore alternative drugs in similar therapeutic classes A10B / A10BX or go back.

References

#	Citation details	PMID
*	Scientific articles
1.	Drug interaction studies with repaglinide: repaglinide on digoxin or theophylline pharmacokinetics and cimetidine on repaglinide pharmacokinetics. Hatorp V, Thomsen MS. J Clin Pharmacol. 2000 Feb;40(2):184-92.	10664925
*	Summary of Product Characteristics
2.	Norwegian medicines agency. Summary of Product Characteristics (SPC). repaglinid.

Citation details

PMID

Scientific articles

Drug interaction studies with repaglinide: repaglinide on digoxin or theophylline pharmacokinetics and cimetidine on repaglinide pharmacokinetics.

Hatorp V, Thomsen MS. J Clin Pharmacol. 2000 Feb;40(2):184-92.

10664925

Summary of Product Characteristics

Norwegian medicines agency. Summary of Product Characteristics (SPC). repaglinid.

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