Acute Porphyria Drug Database

Monograph

V09GA02 - Technetium (99mTc) Tetrofosmin
Propably not porphyrinogenic
PNP

Rationale
Technetium (99mTc) tetrofosmin is administered in low dose and the therapeutic plasma concentration is considered to be insignificant in relation to having potentially porphyrinogenic effects.
Metabolism and pharmacokinetics
After administration, technetium (99mTc) tetrofosmin is rapidly distributed and has a high affinity for myocardial and skeletal muscle (Higley 1993). According to Schreuder and coworkers, the plasma concentration of technetium (99mTc) tetrofosmin is 0.07µM and the hepatic load is therefore probably insignificant (Shcreuder 2016). Approximately 66% of the injected activity is excreted within 48 hours post-injection, with approximately 40% excreted in the urine and 26% in the feces (FDA label). No dug-drug interactions are listed in interaction databases (Lexicomp, Micromedex).
Similar drugs
Explore alternative drugs in similar therapeutic classes V09G / V09GA or go back.

References

# Citation details PMID
*Scientific articles
1. Technetium-99m-1,2-bis[bis(2-ethoxyethyl) phosphino]ethane: human biodistribution, dosimetry and safety of a new myocardial perfusion imaging agent.
Higley B, Smith FW et al. J Nucl Med. 1993 Jan;34(1):30-8.
8418268
2. Radiopharmaceuticals in Acute Porphyria.
Schreuder N, Mamedova I et al. Clin Ther. 2016 Oct;38(10):2239-2247.
27568214
*Government bodies
3. U.S. Food and Drug Administration (FDA). Label information: Myoview. (updated: April 2017).
*Drug interaction databases
4. Lexi-Interact, via UpToDate.
5. Micromedex® 2.0 (online). Drug Interactions). (23.08.2017).

Tradenames
This list comprises raw data collected from different countries. In some cases, a more comprehensive list of available drug packages is included. Consequently, very similar terms may therefore appear multiple times. Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors. We strive to improve it continuously.


Myoview · Tetrofosmine Myoview · Tetrofosmin Myoview · Tetrofosmina Myoview Myoview Myoview Myoview · Tetrofosmin Myoview
 
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