Monograph
A02BA04 - Nizatidine |
Propably not porphyrinogenic |
PNP |
Rationale
In larger parts not metabolised. Alkylamines are mechanism-based inhibitors of CYPs 1A2, 2A6, 2C9, 2D6.
Chemical description
Aminoalkyl thiazol H2-receptor antagonist used in ventricular hypersecretion. A smaller part is metabolized giving rise to sulfoxide (6%), N-oxide (5%) and desmethylnizatidine (7%). About 60% excreted in urine in unchanged form. South African list: use with care. French list: avoid
Similar drugs
Tradenames
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Axid · Nizatidine · Zinga
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