Monograph

C01CA24 - Epinephrine

Not porphyrinogenic

Rationale

Endogenous catecholamine. Non-CYP dependent metabolism. No data pointing to CYP-interaction.

Chemical description

Endogenous catecholamine.

Therapeutic characteristics

Catecholamine used in asthma bronchiale, cardiac arrest, hypersensitivity reactions. Parenterally administered in 0.3-1 mg dose.

Metabolism and pharmacokinetics

Epinephrine (adrenalin) is an endogenous compound. It is very rapidly inactivated by processes which include uptake into adrenergic neurones, diffusion, and enzymatic degradation in the liver and body tissues. Metabolism involves monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT).

IPNet drug reports

Uneventful use reported in 1 patient with acute porphyria.

Similar drugs

Explore alternative drugs in similar therapeutic classes C01C / C01CA or go back.

References

#	Citation details	PMID
*	Scientific articles
1.	MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53.
*	Drug reference publications
2.	Sweetman SC, editor. Martindale: The complete drug reference. Adrenaline. Pharmaceutical Press 2009.

Citation details

PMID

Scientific articles

MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53.

Drug reference publications

Sweetman SC, editor. Martindale: The complete drug reference. Adrenaline. Pharmaceutical Press 2009.

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