Monograph

A06AB02 - Bisacodyl

Propably not porphyrinogenic

Rationale

Probably insignificant systemic exposure.

Chemical description

Contact laxative; enterotablets 5-10 mg/d or supp.10 mg/d. Diphenyl pyridine derivative hydrolyzed in the intestine to desaetylbisacodyl, which is absorbed and excreted in urine and bile as glucuronide. A diphenol is formed in colon which stimulates motility. Only minute amounts reach the system. South African list: use with care

IPNet drug reports

Uneventful use reported in 2 patients with acute porphyria.

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Tradenames

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