Norepinephrine (noradrenaline) is an endogenous catecholamine with non-CYP dependent metabolism. There are no data pointing to CYP-interaction.

Norepinephrine (noradrenaline) is an endogenous catecholamine.

Norepinephrine (noradrenaline) is a direct-acting catecholamine neurotransmitter with pronounced effects on alpha-adrenergic receptors; it also stimulates beta-1 receptors but has little effect on beta-2 receptors. It is the major neurotransmitter in postganglionic adrenergic neurones. The main effects of therapeutic doses of norepinephrine are vasoconstriction and cardiac stimulation, and it is used to produce vasoconstriction and cardiac stimulation as an adjunct to correct hemodynamic imbalances in the treatment of shock that persists after adequate fluid volume replacement. Norepinephrine may also be added to solutions of some local anesthetics to decrease the rate of vascular absorption of the anesthetic, thereby localizing anesthesia and prolonging the duration of anesthesia. Administered by IV infusion.

Norepinephrine is is an endogenous compound. It is very rapidly metabolized in the liver and other tissues by a combination of reactions involving the enzymes catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO). The major metabolites are normetanephrine and 3-methoxy-4-hydroxy mandelic acid (vanillylmandelic acid, VMA), both of which are inactive.

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