Monograph
C01CA06 - Phenylephrine |
Propably not porphyrinogenic |
PNP |
Rationale
/Most recent revision Febr 14 2004 (Pomp). / Hydrophilic substance similar to endogenous adrenaline. Non-CYP metabolism. No data pointing to CYP/NR interaction.
Chemical description
Adrenergic, used parenterally in regional anaesthesia, in severe hypotension and in paroxysmal tachycardia. Nasal and ophtalmic preparations are in use on other indications. Hydrophilic substance with chemical structure similiar to endogenous adrenaline, but lacks one hydroxy-group in the aromatic ring. Oxidative deamination is the predominant metabolic pahway, probably as for endogenous monoamines. Hepatic exposure may exceed the uM range in treatment of severe hypotension, but probably not when used in regional anaesthesia. Elimination half life of the parent compound 2-3 hours. No data pointing to CYP metabolism or other CYP/NR interactions. J Goto et al. Autonomic dysfunction in acute intermittent porphyria. Rinsho Shinkeigaku 1989; 29:774-7. (PMID 2582692).
Similar drugs
Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Biorphen · Fenylefrine 
Phenylephrine 
Fenilefrina · Hidrocloruro Fenilefrina 
Biorphen · Fenilefrina 
Phenylephrine 
Biorphen · Fenylefrin · Metaoxedrin 
Biorphen · Fenylefrin 
Biorphen · Phenylephrine 
Phenylephrine 
Biorphen · Fenylefrin 
Fenylefrin 
Biorphen 
Biorphen
© NAPOS 2025