Monograph

C01CA07 - Dobutamine

Not porphyrinogenic

Rationale

Non-CYP metabolism. No data pointing to CYP-interaction. Four lists stating non-porphyrinogenicity.

Chemical description

Therapeutic characteristics

Synthetic catecholamine used in acute heart failure due to its inotropic effects on the heart. Given in infusion 0.25-1 g/l.

Metabolism and pharmacokinetics

Metabolized in tissues and in the liver. Conjugated to glucuronic acid and methylated by COMT. Excreted in urine within six hours as glucuronide conjugates.

IPNet drug reports

Uneventful use reported in 1 patient with acute porphyria.

Similar drugs

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Tradenames

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